The Scottish philosopher David Hume (1711-1776) is widely regarded as the greatest and most significant English-speaking philosopher and often seen as having had the most influence on the way philosophy is practiced today in the West. His reputation is based not only on the quality of his philosophical thought but also on the breadth and scope of his writings, which ranged over metaphysics, epistemology, morals, politics, religion, and aesthetics.

The Handbook's 38 newly commissioned chapters are divided into six parts: Central Themes; Metaphysics and Epistemology; Passion, Morality and Politics; Aesthetics, History, and Economics; Religion; Hume and the Enlightenment; and After Hume. The volume also features an introduction from editor Paul Russell and a chapter on Hume's biography.

Paul Russell is the accomplished author of various works of both fiction and non-fiction, including several award-winning novels, anthologies, poems, short stories, essays, and book reviews. He attended Oberlin College and later studied at Cornell University, where he earned an M.F.A. in Creative Writing and a Ph.D. in English. Russell has taught English at Vassar College and the University of Exeter, and is a Professor of English at Vassar College. He lives in upstate New York.

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